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New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151.

ABSTRACT: Six new diketopiperazines, (±)-7,8-epoxy-brevianamide Q ((±)-1), (±)-8-hydroxy-brevianamide R ((±)-2), and (±)-8-epihydroxy-brevianamide R ((±)-3), together with four known compounds, (±)-brevianamide R ((±)-4), versicolorin B (5) and averufin (6), were isolated from a marine-derived fungus strain Aspergillus versicolor MF180151, which was recovered from a sediment sample collected from the Bohai Sea, China. The chemical structures were established by 1D- and 2D-NMR spectra and HR-ESI-MS. 1 is the first sample of brevianamides with an epoxy moiety. Their bioactivities were evaluated against Candida albicans, Bacillus subtilis, Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Bacillus Calmette-Guérin. Compounds 1-4 showed no activities against the pathogens, and compounds 5 and 6 showed moderate activities against S. aureus and methicillin-resistant S. aureus.

SUBMITTER: Hu J

PROVIDER: S-EPMC6562876 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151.

Hu Jiansen J Li Zheng Z Gao Jieyu J He Hongtao H Dai Huanqin H Xia Xuekui X Liu Cuihua C Zhang Lixin L Song Fuhang F

Marine drugs 20190502 5

Six new diketopiperazines, (±)-7,8-epoxy-brevianamide Q ((±)-1), (±)-8-hydroxy-brevianamide R ((±)-2), and (±)-8-epihydroxy-brevianamide R ((±)-3), together with four known compounds, (±)-brevianamide R ((±)-4), versicolorin B (5) and averufin (6), were isolated from a marine-derived fungus strain Aspergillus versicolor MF180151, which was recovered from a sediment sample collected from the Bohai Sea, China. The chemical structures were establishe ...[more]

PMID: 31052556

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