Ontology highlight
ABSTRACT:
SUBMITTER: Babeu JP
PROVIDER: S-EPMC6562498 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Babeu Jean-Philippe JP Wilson Samuel D SD Lambert Élie É Lévesque Dominique D Boisvert François-Michel FM Boudreau François F
Cancers 20190505 5
Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor that acts as a master regulator of genes for several endoderm-derived tissues, including the intestine, in which it plays a central role during development and tumorigenesis. To better define the mechanisms by which HNF4α can influence these processes, we identified proteins interacting with HNF4α using stable isotope labelling with amino acids in cell culture (SILAC)-based quantitative proteomics with either immunoprecipitation of g ...[more]