Ontology highlight
ABSTRACT:
SUBMITTER: Camilleri-Robles C
PROVIDER: S-EPMC6562583 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Camilleri-Robles Carlos C Serras Florenci F Corominas Montserrat M
Genes 20190518 5
The GADD45 proteins are induced in response to stress and have been implicated in the regulation of several cellular functions, including DNA repair, cell cycle control, senescence, and apoptosis. In this study, we investigate the role of D-GADD45 during <i>Drosophila</i> development and regeneration of the wing imaginal discs. We find that higher expression of <i>D-GADD45</i> results in JNK-dependent apoptosis, while its temporary expression does not have harmful effects. Moreover, D-GADD45 is ...[more]