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Aspersymmetide A, a New Centrosymmetric Cyclohexapeptide from the Marine-Derived Fungus Aspergillus versicolor.


ABSTRACT: A new centrosymmetric cyclohexapeptide, aspersymmetide A (1), together with a known peptide, asperphenamate (2), was isolated from the fungus Aspergillus versicolor isolated from a gorgonian coral Carijoa sp., collected from the South China Sea. The chemical structure of 1 was elucidated by analyzing its NMR spectroscopy and MS spectrometry data, and the absolute configurations of the amino acids of 1 were determined by Marfey's method and UPLC-MS analysis of the hydrolysate. Aspersymmetide A (1) represents the first example of marine-derived centrosymmetric cyclohexapeptide. Moreover, 1 exhibited weak cytotoxicity against NCI-H292 and A431 cell lines at the concentration of 10 ?M.

SUBMITTER: Hou XM 

PROVIDER: S-EPMC5706052 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Aspersymmetide A, a New Centrosymmetric Cyclohexapeptide from the Marine-Derived Fungus Aspergillus versicolor.

Hou Xue-Mei XM   Zhang Ya-Hui YH   Hai Yang Y   Zheng Ji-Yong JY   Gu Yu-Cheng YC   Wang Chang-Yun CY   Shao Chang-Lun CL  

Marine drugs 20171122 11


A new centrosymmetric cyclohexapeptide, aspersymmetide A (<b>1</b>), together with a known peptide, asperphenamate (<b>2</b>), was isolated from the fungus <i>Aspergillus versicolor</i> isolated from a gorgonian coral <i>Carijoa</i> sp., collected from the South China Sea. The chemical structure of <b>1</b> was elucidated by analyzing its NMR spectroscopy and MS spectrometry data, and the absolute configurations of the amino acids of <b>1</b> were determined by Marfey's method and UPLC-MS analys  ...[more]

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