Ontology highlight
ABSTRACT:
SUBMITTER: Went M
PROVIDER: S-EPMC6563058 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Went Molly M Sud Amit A Li Ni N Johnson David C DC Mitchell Jonathan S JS Kaiser Martin M Houlston Richard S RS
Annals of human genetics 20190215 4
Genomic regions of homozygosity (ROH), detectable in outbred populations, have been implicated as determinants of inherited risk. To examine whether ROH is associated with risk of multiple myeloma (MM), we performed whole-genome homozygosity analysis using single-nucleotide polymorphism genotype data from 2,282 MM cases and 5,197 controls, with replication in an additional 878 MM cases and 7,083 controls. Globally, the distribution of ROH between cases and controls was not significantly differen ...[more]