Ontology highlight
ABSTRACT:
SUBMITTER: Lesniak WG
PROVIDER: S-EPMC6563393 | biostudies-literature | 2019 Jan-Dec
REPOSITORIES: biostudies-literature
Lesniak Wojciech G WG Mease Ronnie C RC Chatterjee Samit S Kumar Dhiraj D Lisok Ala A Wharram Bryan B Kalagadda Venkateswara Rao VR Emens Leisha A LA Pomper Martin G MG Nimmagadda Sridhar S
Molecular imaging 20190101
Expression of programmed cell death ligand 1 (PD-L1) within tumors is an important biomarker for guiding immune checkpoint therapies; however, immunohistochemistry-based methods of detection fail to provide a comprehensive picture of PD-L1 levels in an entire patient. To facilitate quantification of PD-L1 in the whole body, we developed a peptide-based, high-affinity PD-L1 imaging agent labeled with [<sup>18</sup>F]fluoride for positron emission tomography (PET) imaging. The parent peptide, WL12 ...[more]