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A Prospective Life Cycle Assessment (LCA) of Monomer Synthesis: Comparison of Biocatalytic and Oxidative Chemistry.


ABSTRACT: Biotechnological processes are typically perceived to be greener than chemical processes. A life cycle assessment (LCA) was performed to compare the chemical and biochemical synthesis of lactones obtained by Baeyer-Villiger oxidation. The LCA is prospective (based on experiments at a small scale with primary data) because the process is at an early stage. The results show that the synthesis route has no significant effect on the climate change impact [(1.65±0.59)?kg CO2 ?gproduct -1 vs. (1.64±0.67)?kg CO2 ?gproduct -1 ]. Key process performance metrics affecting the environmental impact were evaluated by performing a sensitivity analysis. Recycling of solvents and enzyme were shown to provide an advantage to the enzymatic synthesis. Additionally, the climate change impact was decreased by 71?% if renewable electricity was used. The study shows that comparative LCAs can be used to usefully support decisions at an early stage of process development.

SUBMITTER: Delgove MAF 

PROVIDER: S-EPMC6563695 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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A Prospective Life Cycle Assessment (LCA) of Monomer Synthesis: Comparison of Biocatalytic and Oxidative Chemistry.

Delgove Marie A F MAF   Laurent Achille-B AB   Woodley John M JM   De Wildeman Stefaan M A SMA   Bernaerts Katrien V KV   van der Meer Yvonne Y  

ChemSusChem 20190227 7


Biotechnological processes are typically perceived to be greener than chemical processes. A life cycle assessment (LCA) was performed to compare the chemical and biochemical synthesis of lactones obtained by Baeyer-Villiger oxidation. The LCA is prospective (based on experiments at a small scale with primary data) because the process is at an early stage. The results show that the synthesis route has no significant effect on the climate change impact [(1.65±0.59) kg CO2  g<sub>product</sub> <sup  ...[more]

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