Dataset Information

Seasonal Changes in the Prevalence of Antibiotic-Susceptible Acinetobacter calcoaceticus-baumannii Complex Isolates Result in Increased Multidrug Resistance Rates During Winter Months.

ABSTRACT: Temporal analysis of Acinetobacter calcoaceticus-baumannii complex isolates in a large, US healthcare system demonstrated decreased occurrence of antibiotic-susceptible isolates between November and May, while resistant isolate occurrence was temporally stable. This resulted in 50%-100% seasonal increases of resistance rates. This work offers insight into the phenomenon of Gram-negative pathogen seasonality.

SUBMITTER: Burnham JP

PROVIDER: S-EPMC6563941 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Seasonal Changes in the Prevalence of Antibiotic-Susceptible <i>Acinetobacter calcoaceticus-baumannii</i> Complex Isolates Result in Increased Multidrug Resistance Rates During Winter Months.

Burnham Jason P JP Feldman Mario F MF Calix Juan J JJ

Open forum infectious diseases 20190522 6

Temporal analysis of <i>Acinetobacter calcoaceticus-baumannii</i> complex isolates in a large, US healthcare system demonstrated decreased occurrence of antibiotic-susceptible isolates between November and May, while resistant isolate occurrence was temporally stable. This resulted in 50%-100% seasonal increases of resistance rates. This work offers insight into the phenomenon of Gram-negative pathogen seasonality. ...[more]

PMID: 31214631

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Project description:ObjectivesThe study aimed to investigate the prevalence and epidemiological characteristics of blaNDM-1 (encoding New Delhi metallo-?-lactamase 1) in Enterobacteriaceae and the Acinetobacter calcoaceticus-Acinetobacter baumannii complex (ABC) in China from July 2011 to June 2012.MethodsPCR was used to screen for the presence of blaNDM-1 in all organisms studied. For blaNDM-1-positive strains, 16S rRNA analysis and Analytical Profile Index (API) strips were used to identify the bacterial genus and species. The ABCs were reconfirmed by PCR detection of blaOXA-51-like. Antibiotic susceptibilities of the bacteria were assessed by determining minimum inhibitory concentration (MIC) of them using two-fold agar dilution test, as recommended by the Clinical and Laboratory Standards Institute (CLSI). Molecular typing was performed using pulsed-field gel electrophoresis (PFGE). S1 nuclease-pulsed-field gel electrophoresis (S1-PFGE) and Southern blot hybridization were conducted to ascertain the gene location of blaNDM-1. Conjugation experiments were conducted to determine the transmission of blaNDM-1-positive strains.ResultsAmong 2,170 Enterobacteriaceae and 600 ABCs, seven Enterobacteriaceae strains and two A. calcoaceticus isolates from five different cities carried the blaNDM-1 gene. The seven Enterobacteriaceae strains comprised four Klebsiella pneumoniae, one Enterobacter cloacae, one Enterobacter aerogen and one Citrobacter freundii. All seven were non-susceptible to imipenem, meropenem or ertapenem. Two A. calcoaceticus species were resistant to imipenem and meropenem. Three K. pneumoniae showed the same PFGE profiles. The blaNDM-1 genes of eight strains were localized on plasmids, while one was chromosomal.ConclusionsCompared with previous reports, the numbers and species containing the blaNDM-1 in Enterobacteriaceae have significantly increased in China. Most of them are able to disseminate the gene, which is cause for concern. Consecutive surveillance should be implemented and should also focus on the dissemination of blaNDM-1 among gram-negative clinical isolates.

Dataset Information

Seasonal Changes in the Prevalence of Antibiotic-Susceptible Acinetobacter calcoaceticus-baumannii Complex Isolates Result in Increased Multidrug Resistance Rates During Winter Months.

Publications

Seasonal Changes in the Prevalence of Antibiotic-Susceptible <i>Acinetobacter calcoaceticus-baumannii</i> Complex Isolates Result in Increased Multidrug Resistance Rates During Winter Months.

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