Ontology highlight
ABSTRACT:
SUBMITTER: Zhou B
PROVIDER: S-EPMC6565627 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Zhou Bailing B Zhang Hailong H Su Xiaoqing X Luo Yi Y Li Xiaopeng X Yu Chaoheng C Xie Qibing Q Xia Xuyang X He Gu G Yang Li L
Signal transduction and targeted therapy 20190614
B-cell targeted therapy is effective for autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis (RA), although there are setbacks in RA clinical trials. In this study, we designed a novel B-cell activating factor (BAFF) antagonist: BAFF-Trap, a recombinant glycoprotein with BAFF-binding domains of two BAFF receptors (TACI and Br3) linked to Fc domain of human IgG1. Unlike TACI-Fc, BAFF-Trap bound BAFF but not APRIL (a proliferation-inducing ligand), and significantly s ...[more]