Ontology highlight
ABSTRACT:
SUBMITTER: Tomita T
PROVIDER: S-EPMC6566540 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Tomita Takuya T Matouschek Andreas A
Protein science : a publication of the Protein Society 20190523 7
Proteins in the cell have to be eliminated once their function is no longer desired or they become damaged. Most regulated protein degradation is achieved by a large enzymatic complex called the proteasome. Many proteasome substrates are targeted for degradation by the covalent attachment of ubiquitin molecules. Ubiquitinated proteins can be bound by the proteasome, but for proteolysis to occur the proteasome needs to find a disordered tail somewhere in the target at which it initiates degradati ...[more]