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Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia.


ABSTRACT: Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been considered as important treatment targets in childhood acute lymphoblastic leukemia (ALL). The present research aimed at the identification and characterization of novel fusion genes with potential clinical implications in Mexican children with acute lymphoblastic leukemia. The RNA-sequencing approach was used. Four fusion genes not previously reported were identified: CREBBP-SRGAP2B, DNAH14-IKZF1, ETV6-SNUPN, ETV6-NUFIP1. Although a fusion gene is not sufficient to cause leukemia, it could be involved in the pathogenesis of the disease. Notably, these new translocations were found in genes encoding for hematopoietic transcription factors which are known to play an important role in leukemogenesis and disease prognosis such as IKZF1, CREBBP, and ETV6. In addition, they may have an impact on the prognosis of Mexican pediatric patients with ALL, with the potential to be included in the current risk stratification schemes or used as therapeutic targets.

SUBMITTER: Mata-Rocha M 

PROVIDER: S-EPMC6566803 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia.

Mata-Rocha Minerva M   Rangel-López Angelica A   Jiménez-Hernández Elva E   Morales-Castillo Blanca Angélica BA   González-Torres Carolina C   Gaytan-Cervantes Javier J   Álvarez-Olmos Enrique E   Núñez-Enríquez Juan Carlos JC   Fajardo-Gutiérrez Arturo A   Martín-Trejo Jorge Alfonso JA   Solís-Labastida Karina Anastacia KA   Medina-Sansón Aurora A   Flores-Lujano Janet J   Sepúlveda-Robles Omar Alejandro OA   Peñaloza-González José Gabriel JG   Espinoza-Hernández Laura Eugenia LE   Núñez-Villegas Nora Nancy NN   Espinosa-Elizondo Rosa Martha RM   Cortés-Herrera Beatriz B   Torres-Nava José Refugio JR   Flores-Villegas Luz Victoria LV   Merino-Pasaye Laura Elizabeth LE   Bekker-Méndez Vilma Carolina VC   Velázquez-Aviña Martha Margarita MM   Pérez-Saldívar María Luisa ML   Bautista-Martínez Benito Alejandro BA   Amador-Sánchez Raquel R   González-Avila Ana Itamar AI   Jiménez-Morales Silvia S   Duarte-Rodríguez David Aldebarán DA   Santillán-Juárez Jessica Denisse JD   García-Velázquez Alejandra Jimena AJ   Rosas-Vargas Haydeé H   Mejía-Aranguré Juan Manuel JM  

International journal of molecular sciences 20190515 10


Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been considered as important treatment targets in childhood acute lymphoblastic leukemia (ALL). The present research aimed at the identification and characterization of novel fusion genes with potential clin  ...[more]

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