FOXO1 regulates VEGFA expression and promotes angiogenesis in healing wounds.
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ABSTRACT:
SUBMITTER: Jeon HH
PROVIDER: S-EPMC6566901 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
FOXO1 regulates VEGFA expression and promotes angiogenesis in healing wounds.
Jeon Hyeran Helen HH Yu Quan Q Lu Yongjian Y Spencer Evelyn E Lu Chanyi C Milovanova Tatyana T Yang Yang Y Zhang Chenying C Stepanchenko Olga O Vafa Rameen P RP Coelho Paulo G PG Graves Dana T DT
The Journal of pathology 20180420 3
Angiogenesis is a critical aspect of wound healing. We investigated the role of keratinocytes in promoting angiogenesis in mice with lineage-specific deletion of the transcription factor FOXO1. The results indicate that keratinocyte-specific deletion of Foxo1 reduces VEGFA expression in mucosal and skin wounds and leads to reduced endothelial cell proliferation, reduced angiogenesis, and impaired re-epithelialization and granulation tissue formation. In vitro FOXO1 was needed for VEGFA transcrip ...[more]
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