Dataset Information

Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a ¹H NMR-based metabolomics study.

ABSTRACT:

Background

Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic incubation period. In this study, a proton nuclear magnetic resonance (¹H NMR)-based metabolomics approach was applied in conjunction with multivariate statistical analysis to investigate the altered metabolic profiles in blood serum and urine samples obtained from HAE patients. The aim of the study was to identify the metabolic signatures associated with HAE.

Results

A total of 21 distinct metabolic differences between HAE patients and healthy individuals were identified, and they are associated with perturbations in amino acid metabolism, energy metabolism, glyoxylate and dicarboxylate metabolism. Furthermore, the present results showed that the Fischer ratio, which is the molar ratio of branched-chain amino acids to aromatic amino acids, was significantly lower (P?ConclusionsThe altered Fischer ratio, together with perturbations in metabolic pathways identified in the present study, may provide new insights into the mechanistic understanding of HAE pathogenesis and potential therapeutic interventions.

SUBMITTER: Lin C

PROVIDER: S-EPMC6567409 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Publications

Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a <sup>1</sup>H NMR-based metabolomics study.

Lin Caigui C Chen Zhong Z Zhang Lingqiang L Wei Zhiliang Z Cheng Kian-Kai KK Liu Yueyue Y Shen Guiping G Fan Haining H Dong Jiyang J

Parasites & vectors 20190613 1

<h4>Background</h4>Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic incubation period. In this study, a proton nuclear magnetic resonance (<sup>1</sup>H NMR)-based metabolomics approach was applied in conjunction with multivariate statistical analysis to investigate the altered met ...[more]

PMID: 31196218

Similar Datasets

Project description:OBJECTIVE:This study is aimed at determining the preoperative nutritional status of patients with hepatic alveolar echinococcosis (HAE), and subsequently establish a concise and reasonable nutritional evaluation indicator. The established evaluation method could be used for clinical preoperative risk assessment and prediction of post-operation recovery. METHODS:The basic patient information on height, body weight, BMI and hepatic encephalopathy of 93 HAE patients were examined. Subsequently, abdominal ultrasonography, blood coagulation and liver function tests were done on the patients. Liver function was assessed using the Child-Pugh improved grading method while nutritional status was evaluated using the European Nutrition Risk Screening 2002 (NRS 2002) method. Additional parameters including hospitalization time, the hemoglobin (HGB) level on the 3rd day after the operation, and the number of postoperative complications of HAE patients were also recorded. RESULTS:The NRS 2002 score was negatively correlated with body weight, body mass index (BMI)and albumin (ALB) (P<0.01), and positively correlated with the transverse and longitudinal diameters of the lesions (P<0.01). A worse grading of liver function was associated with a low ALB and a high NRS 2002 score (P<0.01). Results of the NRS 2002 score indicate that the hospitalization time of the normal nutrition group was significantly shorter than that of the malnourished group (P < 0.05). The HGB level of the control group on the 3rd day after the operation was significantly higher than that of the malnourished group (P < 0.05), and the number of postoperative complications was lower than that of malnutrition group (P < 0.05). CONCLUSION:Malnutrition is common in HAE patients. The nutritional status of HAE patients is related to many clinical factors, such as Child-Pugh classification of liver function, size of the lesion, and ALB among others. Although both BMI and ALB can be used as primary screening indicators for malnutrition in HAE patients, NRS 2002 is more reliable and prudent in judging malnutrition in HAE patients. Therefore, BMI and ALB are more suitable for preoperative risk assessment and prediction of postoperative recovery.

Dataset Information

Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a ¹H NMR-based metabolomics study.

Background

Results

Publications

Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a <sup>1</sup>H NMR-based metabolomics study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1H NMR-based metabolomics study.

Background

Results

Publications

Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a <sup>1</sup>H NMR-based metabolomics study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a ¹H NMR-based metabolomics study.