Targeting the IL-1 family members in skin inflammation.
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ABSTRACT:
SUBMITTER: Jensen LE
PROVIDER: S-EPMC3059231 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Publications
Targeting the IL-1 family members in skin inflammation.
Current opinion in investigational drugs (London, England : 2000) 20101101 11
The IL-1 family of cytokines comprises 11 proteins with pro- and anti-inflammatory functions that are mediated through an equally large group of receptors and coreceptors. Dysregulation of the IL-1 system may lead to diseases such as psoriasis, atopic dermatitis, contact dermatitis and cutaneous lupus erythematosus. These inflammatory skin conditions greatly affect quality of life and life expectancy, and their frequencies are increasing. However, treatment options for these diseases are unsatis ...[more]
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