Dataset Information

Prognostic and clinicopathological significance of long noncoding RNA CTD-2510F5.4 in gastric cancer.

ABSTRACT: BACKGROUND:Compelling studies have demonstrated the correlation between aberrant expressed lncRNAs and human cancers, and revealed promise of these lncRNAs as biomarkers in predicting patients' survival and outcome. METHODS:We downloaded the RNA-seq data from the Cancer Genome Atlas, and screened out DEGs and DELs between gastric cancer tissues and normal gastric tissues. By bioinformatics analysis, we identified CTD-2510F5.4 was a malignant phenotype associated lncRNA. The expression levels of CTD-2510F5.4 in tissues were detected by ISH, and the relationships between CTD-2510F5.4 expression and clinicopathological characteristics were analyzed by statistical analysis. RESULTS:By bioinformatics analysis and functional analysis, we identified CTD-2510F5.4 was a malignant phenotype associated lncRNA of gastric cancer that potentially regulated cell cycle and apoptosis. CTD-2510F5.4 expression was significantly higher in gastric cancers, and was correlated with pathological grade, vascular or nerve invasion, AJCC TNM stage and OS. Moreover, gastric cancer patients with high CTD-2510F5.4 expression showed significantly shorter MST. High CTD-2510F5.4 expression was a independent risk factor for gastric cancers at pathological grade < III and without vascular or nerve invasion. CONCLUSIONS:We identified CTD-2510F5.4 was a malignant phenotype associated lncRNA potentially involved in the pathogenesis of gastric cancer. Our data also supported the clinical potential of CTD-2510F5.4 being a diagnostic and prognostic biomarker for gastric cancer.

SUBMITTER: Wang Z

PROVIDER: S-EPMC6570689 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Prognostic and clinicopathological significance of long noncoding RNA CTD-2510F5.4 in gastric cancer.

Wang Zhe Z Qin Baoli B

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20181217 4

<h4>Background</h4>Compelling studies have demonstrated the correlation between aberrant expressed lncRNAs and human cancers, and revealed promise of these lncRNAs as biomarkers in predicting patients' survival and outcome.<h4>Methods</h4>We downloaded the RNA-seq data from the Cancer Genome Atlas, and screened out DEGs and DELs between gastric cancer tissues and normal gastric tissues. By bioinformatics analysis, we identified CTD-2510F5.4 was a malignant phenotype associated lncRNA. The expres ...[more]

PMID: 30560474

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Dataset Information

Prognostic and clinicopathological significance of long noncoding RNA CTD-2510F5.4 in gastric cancer.

Publications

Prognostic and clinicopathological significance of long noncoding RNA CTD-2510F5.4 in gastric cancer.

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