Ontology highlight
ABSTRACT:
SUBMITTER: Catala M
PROVIDER: S-EPMC6572803 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Catala Mathieu M Abou Elela Sherif S
Communications biology 20190617
Cell cycle progression depends on phase-specific gene expression. Here we show that the nuclear RNA degradation machinery plays a lead role in promoting cell cycle-dependent gene expression by triggering promoter-dependent co-transcriptional RNA degradation. Single molecule quantification of RNA abundance in different phases of the cell cycle indicates that relative curtailment of gene expression in certain phases is attained even when transcription is not completely inhibited. When nuclear ribo ...[more]