Ontology highlight
ABSTRACT:
SUBMITTER: Posse V
PROVIDER: S-EPMC3973307 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Posse Viktor V Hoberg Emily E Dierckx Anke A Shahzad Saba S Koolmeister Camilla C Larsson Nils-Göran NG Wilhelmsson L Marcus LM Hällberg B Martin BM Gustafsson Claes M CM
Nucleic acids research 20140120 6
Mammalian mitochondrial transcription is executed by a single subunit mitochondrial RNA polymerase (Polrmt) and its two accessory factors, mitochondrial transcription factors A and B2 (Tfam and Tfb2m). Polrmt is structurally related to single-subunit phage RNA polymerases, but it also contains a unique N-terminal extension (NTE) of unknown function. We here demonstrate that the NTE functions together with Tfam to ensure promoter-specific transcription. When the NTE is deleted, Polrmt can initiat ...[more]