Dataset Information

A Unique Personalized Nutrition Program Facilitates Lifestyle Behavior Changes: Novel Insights from HABIT's Personalized Approach to Health (PATH) Study (P15-020-19)

ABSTRACT: Abstract

Objectives

A key to a successful personalized nutrition (PN) strategy is tailoring the behavior intervention to achieve sustained behavior change consistent with desired health outcomes. The objective of this study was to evaluate the impact of a digitally-delivered, systems biology-based PN program (Habit, LLC, Oakland, CA), that included nutrition and behavior advice, and meals.

Methods

In this single-arm, multi-phase, open-label study (clinicaltrials.gov: NCT03424395), participants (n = 107; 67% female), 30–59 years of age, were provided a Fitbit® Activity Tracker and instructions to complete an at-home kit that included collection of DNA and capillary blood before and after (30 and 120 min) consuming a mixed macronutrient challenge beverage. Lifestyle behavior data and activity levels were collected at baseline. Participants completed a 10-week control phase and a 10-week PN program intervention phase that included tailored nutrition and behavior advice, and meals (2 meals/day, 5 days/week). Validated quality of life, perceived stress, diet self-efficacy, and eating behavior questionnaires were administered to assess behavior before and after the intervention. Data from 73 compliant participants (66% female) were included in the analysis. Anthropometric and biological results were used to categorize participants into subgroups including Protein Seekers (PS) and Range Seekers (RS).

Results

Participants reported feeling fuller faster after the intervention, relative to before (P = 0.002), which could be linked to the dietary recommendations and behavior advice. Analysis by gender showed men reported more control over their eating patterns during negative events at baseline, compared to women (P = 0.005). This difference was not evident at the end of the intervention with women reporting slightly more, and men slightly less control. PS entered the study with a higher weight and BMI (P < 0.001 for both) and reported eating more quickly than RS (P = 0.003). This difference diminished, and by the end of the intervention PS did not differ from RS which could reflect the tailored advice provided.

Conclusions

These and other data provide novel insights on how a tailored personalized intervention that targeted food behavior may help drive positive changes in health outcomes.

Funding Sources

Habit, LLC.

SUBMITTER: Winters B

PROVIDER: S-EPMC6574210 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Project description:Abstract Objectives This study evaluates the impact of a digitally-delivered systems biology-based personalized nutrition (PN) program (Habit LLC, Oakland, CA), that included nutrition and behavior advice, and meals. Methods In this single-arm, multi-phase, open-label study (clinicaltrials.gov: NCT03424395), participants (n = 107; 67% female) were provided a Fitbit® Activity Tracker and completed an at-home kit that included collection of DNA and capillary blood before and after (30 and 120 min) consuming a mixed macronutrient challenge beverage. Participants completed a 10-week run-in and 10-week PN program intervention phase. The intervention included personalized nutrition and behavior advice and meals (2 meals/day; 5 days/week) tailored to dietary subgroups. Here we report on changes in diet, anthropometrics, and biomarkers of two subgroups (Range Seekers [RS] and Protein Seekers [PS]) that differed in anthropometrics and biological measures at baseline and were provided different dietary recommendations. Results At baseline, there were no differences between groups in nutrients assessed, however, compared to RS (n = 48), PS (n = 22) had higher BMI, weight, body fat %, waist and hip circumference (all P < 0.0001), HOMA-IR, age, (both P < 0.01), muscle mass, diastolic blood pressure, hepatic insulin resistance index and c-peptide (all P < 0.05). After the intervention, both groups reduced intakes of calories (P < 0.001) and % calories from saturated fat and monounsaturated fat (both P < 0.05). Intakes of total fat, saturated fat, and sodium (all P < 0.001) as well as carbohydrate and total sugars (both P < 0.05) were also reduced. RS and PS increased vitamin C and fiber intakes (P < 0.001). PS, but not RS, received advice to increase protein intake, accordingly % calories from protein increased in PS by 28% (P < 0.001). PS also increased intake of b-carotene and vitamin A (P < 0.01). BMI and weight decreased in both groups (P < 0.001) after the intervention, with greater extent of weight loss observed in PS. In addition to weight loss in PS, a reduction in total and LDL cholesterol (P < 0.001) was observed. Conclusions Together, these results support the efficacy of a digitally-delivered PN program, differentiated by subtype, in improving dietary patterns and health indicators. Funding Sources Habit, LLC.

Project description:Adolescence is a critical period, because major physical and psychologic changes occur during a very short period of time. Changes in dietary habits may induce different types of nutritional disorders and are likely to track into adulthood. The aim of this review is to describe the key findings related to nutritional status in European adolescents participating in the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) study. We performed a cross-sectional study in 3528 (1845 females) adolescents aged 12.5–17.5 y. Birth weight was negatively associated with abdominal fat mass in adolescents and serum leptin concentrations (in female adolescents), providing additional evidence for a programming effect of birth weight on energy homeostasis control. Breakfast consumption was associated with lower body fat content and healthier cardiovascular profile. Adolescents eat half of the recommended amount of fruit and vegetables and less than two-thirds of the recommended amount of milk and milk products but consume more meat and meat products, fats, and sweets than recommended. For beverage consumption, sugar-sweetened beverages, sweetened milk, low-fat milk, and fruit juice provided the highest amount of energy. Although the intakes of saturated fatty acids (FAs) and salt were high, the intake of polyunsaturated FAs was low. Adolescents spent, on average, 9 h/d of their waking time (66–71% and 70–73% of the registered time in boys and girls, respectively) in sedentary activities. Factors associated with adolescents’ sedentary behavior included the following: 1) age; 2) media availability in the bedroom; 3) sleeping time; 4) breakfast consumption; and 5) season. Sedentary time was also associated with cardiovascular risk factors and bone mineral content. In European adolescents, deficient concentrations were identified for plasma folate (15%), vitamin D (15%), pyridoxal 5?-phosphate (5%), ?-carotene (25%), and vitamin E (5%). Scientists and public health authorities should raise awareness of the importance of a healthy and sustainable lifestyle as a foundation of the health of the European population, now and in the future.

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