Ontology highlight
ABSTRACT:
SUBMITTER: Hill CM
PROVIDER: S-EPMC6579533 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Hill Cristal M CM Laeger Thomas T Dehner Madeleine M Albarado Diana C DC Clarke Blaise B Wanders Desiree D Burke Susan J SJ Collier J Jason JJ Qualls-Creekmore Emily E Solon-Biet Samantha M SM Simpson Stephen J SJ Berthoud Hans-Rudolf HR Münzberg Heike H Morrison Christopher D CD
Cell reports 20190601 10
Reduced dietary protein intake induces adaptive physiological changes in macronutrient preference, energy expenditure, growth, and glucose homeostasis. We demonstrate that deletion of the FGF21 co-receptor βKlotho (Klb) from the brain produces mice that are unable to mount a physiological response to protein restriction, an effect that is replicated by whole-body deletion of FGF21. Mice forced to consume a low-protein diet exhibit reduced growth, increased energy expenditure, and a resistance to ...[more]