The ribosome moves: RNA mechanics and translocation.
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ABSTRACT:
SUBMITTER: Noller HF
PROVIDER: S-EPMC6581036 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
The ribosome moves: RNA mechanics and translocation.
Noller Harry F HF Lancaster Laura L Zhou Jie J Mohan Srividya S
Nature structural & molecular biology 20171201 12
During protein synthesis, mRNA and tRNAs must be moved rapidly through the ribosome while maintaining the translational reading frame. This process is coupled to large- and small-scale conformational rearrangements in the ribosome, mainly in its rRNA. The free energy from peptide-bond formation and GTP hydrolysis is probably used to impose directionality on those movements. We propose that the free energy is coupled to two pawls, namely tRNA and EF-G, which enable two ratchet mechanisms to act s ...[more]
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