Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC6582366 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Wang Bo B Xie Zhong-Ru ZR Chen Jiawen J Wu Yinghao Y
Structure (London, England : 1993) 20180830 10
The information of how two proteins interact is embedded in the atomic details of their binding interfaces. These interactions, spatial-temporally coordinating each other as a network in a variable cytoplasmic environment, dominate almost all biological functions. A feasible and reliable computational model is highly demanded to realistically simulate these cellular processes and unravel the complexities beneath them. We therefore present a multiscale framework that integrates simulations on two ...[more]