Ontology highlight
ABSTRACT:
SUBMITTER: Gushchanskaia ES
PROVIDER: S-EPMC6582410 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Gushchanskaia Ekaterina S ES Esse Ruben R Ma Qicheng Q Lau Nelson C NC Grishok Alla A
Nucleic acids research 20190601 11
The nematode Caenorhabditis elegans contains several types of endogenous small interfering RNAs (endo-siRNAs) produced by RNA-dependent RNA polymerase (RdRP) complexes. Both 'silencing' siRNAs bound by Worm-specific Argonautes (WAGO) and 'activating' siRNAs bound by the CSR-1 Argonaute require the DRH-3 helicase, an RdRP component. Here, we show that, in the drh-3(ne4253) mutant deficient in RdRP-produced secondary endo-siRNAs, the silencing histone mark H3K9me3 is largely depleted, whereas in t ...[more]