Ontology highlight
ABSTRACT:
SUBMITTER: Love EA
PROVIDER: S-EPMC6582441 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20190207 6
Antibody-drug conjugates (ADCs) are a growing class of therapeutics that harness the specificity of antibodies and the cell-killing potency of small-molecule drugs. Beyond cytotoxics, there are few examples of the application of an ADC approach to difficult drug discovery targets. Here, we present the initial development of a non-internalising ADC, with a view to selectively inhibiting an extracellular protein. Employing the wellinvestigated matrix metalloproteinase-9 (MMP-9) as our model, we ad ...[more]