Ontology highlight
ABSTRACT:
SUBMITTER: Schulz-Heddergott R
PROVIDER: S-EPMC6582949 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Schulz-Heddergott Ramona R Stark Nadine N Edmunds Shelley J SJ Li Jinyu J Conradi Lena-Christin LC Bohnenberger Hanibal H Ceteci Fatih F Greten Florian R FR Dobbelstein Matthias M Moll Ute M UM
Cancer cell 20180801 2
Over half of colorectal cancers (CRCs) harbor TP53 missense mutations (mutp53). We show that the most common mutp53 allele R248Q (p53<sup>Q</sup>) exerts gain of function (GOF) and creates tumor dependence in mouse CRC models. mutp53 protein binds Stat3 and enhances activating Stat3 phosphorylation by displacing the phosphatase SHP2. Ablation of the p53<sup>Q</sup> allele suppressed Jak2/Stat3 signaling, growth, and invasiveness of established, mutp53-driven tumors. Treating tumor-bearing mice w ...[more]