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Induced pluripotent stem cells in disease modelling and drug discovery.

ABSTRACT: The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked widespread enthusiasm for the development of new models of human disease, enhanced platforms for drug discovery and more widespread use of autologous cell-based therapy. Early studies using directed differentiation of iPSCs frequently uncovered cell-level phenotypes in monogenic diseases, but translation to tissue-level and organ-level diseases has required development of more complex, 3D, multicellular systems. Organoids and human-rodent chimaeras more accurately mirror the diverse cellular ecosystems of complex tissues and are being applied to iPSC disease models to recapitulate the pathobiology of a broad spectrum of human maladies, including infectious diseases, genetic disorders and cancer.

SUBMITTER: Rowe RG

PROVIDER: S-EPMC6584039 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Induced pluripotent stem cells in disease modelling and drug discovery.

Rowe R Grant RG Daley George Q GQ

Nature reviews. Genetics 20190701 7

The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked widespread enthusiasm for the development of new models of human disease, enhanced platforms for drug discovery and more widespread use of autologous cell-based therapy. Early studies using directed differentiation of iPSCs frequently uncovered cell-level phenotypes in monogenic diseases, but translation to tissue-level and organ-level diseases has required development of more complex, 3D, multicellular systems. O ...[more]

PMID: 30737492

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