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Induced pluripotent stem cells in cardiovascular drug discovery.

ABSTRACT: The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells exhibiting inherited traits and disorders. Use of these cells in high throughput analyses should broaden our insight into fundamental disease mechanisms and provide many benefits for patients, including new therapeutics and individually tailored therapies. Here we review recent progress in generating induced pluripotent stem cell-based models of cardiovascular disease and their multiple applications in drug development.

SUBMITTER: Mercola M

PROVIDER: S-EPMC3706265 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Induced pluripotent stem cells in cardiovascular drug discovery.

Mercola Mark M Colas Alexandre A Willems Erik E

Circulation research 20130201 3

The unexpected discovery that somatic cells can be reprogrammed to a pluripotent state yielding induced pluripotent stem cells has made it possible to produce cardiovascular cells exhibiting inherited traits and disorders. Use of these cells in high throughput analyses should broaden our insight into fundamental disease mechanisms and provide many benefits for patients, including new therapeutics and individually tailored therapies. Here we review recent progress in generating induced pluripoten ...[more]

PMID: 23371902

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