Ontology highlight
ABSTRACT:
SUBMITTER: Der E
PROVIDER: S-EPMC6584054 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nature immunology 20190520 7
The molecular and cellular processes that lead to renal damage and to the heterogeneity of lupus nephritis (LN) are not well understood. We applied single-cell RNA sequencing (scRNA-seq) to renal biopsies from patients with LN and evaluated skin biopsies as a potential source of diagnostic and prognostic markers of renal disease. Type I interferon (IFN)-response signatures in tubular cells and keratinocytes distinguished patients with LN from healthy control subjects. Moreover, a high IFN-respon ...[more]