Ontology highlight
ABSTRACT:
SUBMITTER: Gehrke EJ
PROVIDER: S-EPMC6584129 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Gehrke Emma J EJ Zhang Xiafei X Pimentel-Elardo Sheila M SM Johnson Andrew R AR Rees Christiaan A CA Jones Stephanie E SE Hindra Gehrke Sebastian S SS Turvey Sonya S Boursalie Suzanne S Hill Jane E JE Carlson Erin E EE Nodwell Justin R JR Elliot Marie A MA
eLife 20190619
Lsr2 is a nucleoid-associated protein conserved throughout the actinobacteria, including the antibiotic-producing <i>Streptomyces. Streptomyces</i> species encode paralogous Lsr2 proteins (Lsr2 and Lsr2-like, or LsrL), and we show here that of the two, Lsr2 has greater functional significance. We found that Lsr2 binds AT-rich sequences throughout the chromosome, and broadly represses gene expression. Strikingly, specialized metabolic clusters were over-represented amongst its targets, and the cr ...[more]