Intrinsic Spine Dynamics Are Critical for Recurrent Network Learning in Models With and Without Autism Spectrum Disorder.
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ABSTRACT:
SUBMITTER: Humble J
PROVIDER: S-EPMC6585147 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
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Intrinsic Spine Dynamics Are Critical for Recurrent Network Learning in Models With and Without Autism Spectrum Disorder.
Humble James J Hiratsuka Kazuhiro K Kasai Haruo H Toyoizumi Taro T
Frontiers in computational neuroscience 20190613
It is often assumed that Hebbian synaptic plasticity forms a cell assembly, a mutually interacting group of neurons that encodes memory. However, in recurrently connected networks with pure Hebbian plasticity, cell assemblies typically diverge or fade under ongoing changes of synaptic strength. Previously assumed mechanisms that stabilize cell assemblies do not robustly reproduce the experimentally reported unimodal and long-tailed distribution of synaptic strengths. Here, we show that augmentin ...[more]
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