Ontology highlight
ABSTRACT:
SUBMITTER: Chen M
PROVIDER: S-EPMC6585363 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Chen Mengping M Gao Chen C Yu Jiayu J Ren Shuxun S Wang Menglong M Wynn R Max RM Chuang David T DT Wang Yibin Y Sun Haipeng H
Journal of the American Heart Association 20190601 11
Background Branched-chain amino acid (BCAA) catabolic defect is an emerging metabolic hallmark in failing hearts in human and animal models. The therapeutic impact of targeting BCAA catabolic flux under pathological conditions remains understudied. Methods and Results BT2 (3,6-dichlorobenzo[b]thiophene-2-carboxylic acid), a small-molecule inhibitor of branched-chain ketoacid dehydrogenase kinase, was used to enhance BCAA catabolism. After 2 weeks of transaortic constriction, mice with significan ...[more]