Zwitterionic Janus Dendrimer with distinct functional disparity for enhanced protein delivery.

ABSTRACT: The development of a facile protein delivery vehicle is challenging and remains an unmet demand for clinical applications. The well-defined structure and functionality of a nanocarrier are highly desirable for the reproducibility and regulatory compliance. Herein, we report for the first time a novel Janus dendrimer (JD) system, comprised of two distinct dendrons with superior protein binding and protein repelling properties, respectively, for efficient spontaneous protein loading and enhanced in vivo protein delivery. Core-forming dendron is tethered with a combination of charged and hydrophobic moieties, which coat protein surface efficiently via the multivalent and synergistic interactions. Zwitterionic peripheries on the counter dendron endow the nanoparticle (<20 nm) with a highly hyd

SUBMITTER: Wang L 

PROVIDER: S-EPMC6585461 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature