Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age- vs. Genotype-Related Differences.
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ABSTRACT:
SUBMITTER: Ducker CM
PROVIDER: S-EPMC6585622 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age- vs. Genotype-Related Differences.
Dücker Christof M CM Brockmöller Jürgen J
Clinical pharmacology and therapeutics 20180402 3
Older persons may particularly benefit from pharmacogenetic diagnostics, but there is little clinical evidence on that question. We quantitatively analyzed the effects of age and genotype in drugs with consensus on a therapeutically relevant impact of a genotype. Assuming additive effects of age and genotype, drugs may be classified in groups with different priorities to consider either age, or genotype, or both, in therapy. Particularly interesting were those studies specifically analyzing the ...[more]
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