Ontology highlight
ABSTRACT:
SUBMITTER: Massarella J
PROVIDER: S-EPMC6585761 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Massarella Joseph J Ariyawansa Jay J Natarajan Jaya J Francke Stephan S Murtaugh Thomas T DeLemos Byron B Vaughan Subusola S Fonseca Sergio S
Clinical pharmacology in drug development 20180518 1
We evaluated the effects of therapeutic and supratherapeutic doses of tramadol hydrochloride on the corrected QT (QTc) interval in healthy adults (aged 18-55 years) in a randomized, phase I, double-blind, placebo- and positive-controlled, multiple-dose, 4-way crossover study. Participants were randomized to receive 1 of 4 treatments (A-D), 1 each in 4 treatment periods (1-4), separated by a washout period (7-15 days). Treatment A comprised tramadol 400 mg (therapeutic dose) on days 1 through 3, ...[more]