Ontology highlight
ABSTRACT:
SUBMITTER: Vormfelde SV
PROVIDER: S-EPMC7719381 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Vormfelde Stefan Viktor SV Pezous Nicole N Lefèvre Gilbert G Kolly Carine C Neumann Ulf U Jordaan Pierre P Ufer Mike M Legangneux Eric E
Clinical and translational science 20200723 6
Umibecestat, an orally active β-secretase inhibitor, reduces the production of amyloid beta-peptide that accumulates in the brain of patients with Alzheimer's disease. The echocardiogram effects of umibecestat, on QTcF (Fridericia-corrected QT), on PR and QRS and heart rate (HR), were estimated by concentration-effect modeling. Three phase I/II studies with durations up to 3 months, with 372 healthy subjects over a wide age range, including both sexes and 2 ethnicities, were pooled, providing a ...[more]