Ontology highlight
ABSTRACT:
SUBMITTER: Morshedian A
PROVIDER: S-EPMC6586478 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Neuron 20190502 6
While rods in the mammalian retina regenerate rhodopsin through a well-characterized pathway in cells of the retinal pigment epithelium (RPE), cone visual pigments are thought to regenerate in part through an additional pathway in Müller cells of the neural retina. The proteins comprising this intrinsic retinal visual cycle are unknown. Here, we show that RGR opsin and retinol dehydrogenase-10 (Rdh10) convert all-trans-retinol to 11-cis-retinol during exposure to visible light. Isolated retinas ...[more]