Ontology highlight
ABSTRACT:
SUBMITTER: Jin N
PROVIDER: S-EPMC6586626 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Nature communications 20190620 1
One of the biggest hurdles for the development of metabolism-targeted therapies is to identify the responsive tumor subsets. However, the metabolic vulnerabilities for most human cancers remain unclear. Establishing the link between metabolic signatures and the oncogenic alterations of receptor tyrosine kinases (RTK), the most well-defined cancer genotypes, may precisely direct metabolic intervention to a broad patient population. By integrating metabolomics and transcriptomics, we herein show t ...[more]