Dataset Information

T-bet⁺ lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer.

ABSTRACT:

Purpose

T-box transcription factor 21 (T-bet), which is the master regulator of effector T-cell activation, is derived by stimulation of T-cell receptors. In this study, we focused on T-bet and examined the function of activated T cells.

Methods

This study included 242 patients with primary triple-negative breast cancer (TNBC) who underwent resection without neoadjuvant chemotherapy between January 2004 and December 2014. The immunohistochemistry scoring for CD8 and T-bet expression on tumor-infiltrating lymphocytes (TILs) was defined as???30 per 6.25?×?10^-3 mm².

Results

Of the 242 TNBC cases, CD8 was positively expressed in 127 (52.5%) tumors, and T-bet was positively expressed in 67 (27.7%) tumors. T-bet expression was significantly correlated with CD8 expression (p?+ tumors had longer overall survival (OS) compared with patients with T-bet^- tumors (p?=?0.047). The combination of CD8⁺ and T-bet⁺ was associated with a better recurrence-free survival (RFS) and OS compared to CD8⁺/T-bet^- tumors (p?=?0.037 and p?=?0.024, respectively). Adjuvant chemotherapy provided significantly greater benefit to patients with T-bet⁺ tumors (p?=?0.031 for RFS, p?=?0.0003 for OS). Multivariate analysis revealed that T-bet expression on TILs was an independent and positive prognostic indicator (HR?=?0.36, 95% confidence interval (CI) 0.12-0.94, p?=?0.037 for RFS, HR?=?0.30, 95% CI 0.07-0.95, p?=?0.039 for OS).

Conclusions

OS was significantly improved for patients with high T-bet-expressing TILs in TNBC. Thus, T-bet may be a predictive indicator for survival and various immunotherapy strategies in TNBC.

SUBMITTER: Mori H

PROVIDER: S-EPMC6586701 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Publications

T-bet<sup>+</sup> lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer.

Mori Hitomi H Kubo Makoto M Kai Masaya M Yamada Mai M Kurata Kanako K Kawaji Hitomi H Kaneshiro Kazuhisa K Osako Tomofumi T Nishimura Reiki R Arima Nobuyuki N Okido Masayuki M Kishimoto Junji J Oda Yoshinao Y Nakamura Masafumi M

Breast cancer research and treatment 20190508 3

<h4>Purpose</h4>T-box transcription factor 21 (T-bet), which is the master regulator of effector T-cell activation, is derived by stimulation of T-cell receptors. In this study, we focused on T-bet and examined the function of activated T cells.<h4>Methods</h4>This study included 242 patients with primary triple-negative breast cancer (TNBC) who underwent resection without neoadjuvant chemotherapy between January 2004 and December 2014. The immunohistochemistry scoring for CD8 and T-bet expressi ...[more]

PMID: 31069590

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Dataset Information

T-bet⁺ lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer.

Purpose

Methods

Results

Conclusions

Publications

T-bet<sup>+</sup> lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

T-bet+ lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer.

Purpose

Methods

Results

Conclusions

Publications

T-bet<sup>+</sup> lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

T-bet⁺ lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer.