Ontology highlight
ABSTRACT:
SUBMITTER: Filia A
PROVIDER: S-EPMC6586881 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Filia Anastasia A Droop Alastair A Harland Mark M Thygesen Helene H Randerson-Moor Juliette J Snowden Helen H Taylor Claire C Diaz Joey Mark S JMS Pozniak Joanna J Nsengimana Jérémie J Laye Jon J Newton-Bishop Julia A JA Bishop D Timothy DT
Scientific reports 20190620 1
Systematic tumour profiling is essential for biomarker research and clinically for assessing response to therapy. Solving the challenge of delivering informative copy number (CN) profiles from formalin-fixed paraffin embedded (FFPE) material, the only likely readily available biospecimen for most cancers, involves successful processing of small quantities of degraded DNA. To investigate the potential for analysis of such lesions, whole-genome CNVseq was applied to 300 FFPE primary tumour samples ...[more]