Mining the deep Red-Sea brine pool microbial community for anticancer therapeutics.

ABSTRACT:

Background

Microbial species in the brine pools of the Red Sea and the brine pool-seawater interfaces are exposed to high temperature, high salinity, low oxygen levels and high concentrations of heavy metals. As adaptations to these harsh conditions require a large suite of secondary metabolites, these microbes have a huge potential as a source of novel anticancer molecules.

Methods

A total of 60 ethyl-acetate extracts of newly isolated strains from extreme environments of the Red-Sea were isolated and tested against several human cancer cell lines for potential cytotoxic and apoptotic activities.

Results

Isolates from the Erba brine-pool accounted for 50% of active bacterial extracts capable of inducing 30% or greater inhibition of cell growth. Among the 60 extracts

SUBMITTER: Esau L 

PROVIDER: S-EPMC6587256 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature