Ontology highlight
ABSTRACT:
SUBMITTER: Girard E
PROVIDER: S-EPMC6587727 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Girard Elodie E Eon-Marchais Séverine S Olaso Robert R Renault Anne-Laure AL Damiola Francesca F Dondon Marie-Gabrielle MG Barjhoux Laure L Goidin Didier D Meyer Vincent V Le Gal Dorothée D Beauvallet Juana J Mebirouk Noura N Lonjou Christine C Coignard Juliette J Marcou Morgane M Cavaciuti Eve E Baulard Céline C Bihoreau Marie-Thérèse MT Cohen-Haguenauer Odile O Leroux Dominique D Penet Clotilde C Fert-Ferrer Sandra S Colas Chrystelle C Frebourg Thierry T Eisinger François F Adenis Claude C Fajac Anne A Gladieff Laurence L Tinat Julie J Floquet Anne A Chiesa Jean J Giraud Sophie S Mortemousque Isabelle I Soubrier Florent F Audebert-Bellanger Séverine S Limacher Jean-Marc JM Lasset Christine C Lejeune-Dumoulin Sophie S Dreyfus Hélène H Bignon Yves-Jean YJ Longy Michel M Pujol Pascal P Venat-Bouvet Laurence L Bonadona Valérie V Berthet Pascaline P Luporsi Elisabeth E Maugard Christine M CM Noguès Catherine C Delnatte Capucine C Fricker Jean-Pierre JP Gesta Paul P Faivre Laurence L Lortholary Alain A Buecher Bruno B Caron Olivier O Gauthier-Villars Marion M Coupier Isabelle I Servant Nicolas N Boland Anne A Mazoyer Sylvie S Deleuze Jean-François JF Stoppa-Lyonnet Dominique D Andrieu Nadine N Lesueur Fabienne F
International journal of cancer 20181113 8
Pathogenic variants in BRCA1 and BRCA2 only explain the underlying genetic cause of about 10% of hereditary breast and ovarian cancer families. Because of cost-effectiveness, multigene panel testing is often performed even if the clinical utility of testing most of the genes remains questionable. The purpose of our study was to assess the contribution of rare, deleterious-predicted variants in DNA repair genes in familial breast cancer (BC) in a well-characterized and homogeneous population. We ...[more]