Proteins associated with incident metabolic syndrome in population-based cohorts.

ABSTRACT:

Background

The metabolic syndrome (MetS) identifies persons with clustering of multiple cardiometabolic risk factors. The underlying pathology inducing this clustering is not fully known. We used a targeted proteomics assay to identify associations of circulating proteins with MetS and its components, cross-sectionally and longitudinally.

Methods

We explored and validated associations of 86 cardiovascular proteins, assessed using a proximity extension assay, with the MetS in two independent cohorts; the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS, n = 996) and Uppsala Longitudinal Study of Adult Men (ULSAM, n = 785). The analyses were adjusted for smoking, exercise habits, education, and energy and alcohol intake.

Results

Nine proteins were

SUBMITTER: Lind L 

PROVIDER: S-EPMC8579529 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature