Ontology highlight
ABSTRACT:
SUBMITTER: Mari SA
PROVIDER: S-EPMC6588182 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Mari Stefania A SA Wegmann Susanne S Tepper Katharina K Hyman Bradley T BT Mandelkow Eva-Maria EM Mandelkow Eckhard E Müller Daniel J DJ
Nano letters 20180417 5
Misfolding and aggregation of the neuronal, microtubule-associated protein tau is involved in the pathogenesis of Alzheimer's disease and tauopathies. It has been proposed that neuronal membranes could play a role in tau release, internalization, and aggregation and that tau aggregates could exert toxicity via membrane permeabilization. Whether and how tau interacts with lipid membranes remains a matter of discussion. Here, we characterize the interaction of full-length human tau (htau40) with s ...[more]