Ontology highlight
ABSTRACT:
SUBMITTER: Grassmeyer JJ
PROVIDER: S-EPMC6588344 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Grassmeyer Justin J JJ Cahill Asia L AL Hays Cassandra L CL Barta Cody C Quadros Rolen M RM Gurumurthy Channabasavaiah B CB Thoreson Wallace B WB
eLife 20190607
To encode light-dependent changes in membrane potential, rod and cone photoreceptors utilize synaptic ribbons to sustain continuous exocytosis while making rapid, fine adjustments to release rate. Release kinetics are shaped by vesicle delivery down ribbons and by properties of exocytotic Ca<sup>2+</sup> sensors. We tested the role for synaptotagmin-1 (Syt1) in photoreceptor exocytosis by using novel mouse lines in which Syt1 was conditionally removed from rods or cones. Photoreceptors lacking S ...[more]