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Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor.


ABSTRACT: Knowing how biomarker levels vary within biological fluids over time can produce valuable insight into tissue physiology and pathology, and could inform personalised clinical treatment. We describe here a wearable sensor for monitoring biomolecule levels that combines continuous fluid sampling with in situ analysis using wet-chemical assays (with the specific assay interchangeable depending on the target biomolecule). The microfluidic device employs a droplet flow regime to maximise the temporal response of the device, using a screw-driven push-pull peristaltic micropump to robustly produce nanolitre-sized droplets. The fully integrated sensor is contained within a small (palm-sized) footprint, is fully autonomous, and features high measurement frequency (a measurement every few seconds) meaning deviations from steady-state levels are quickly detected. We demonstrate how the sensor can track perturbed glucose and lactate levels in dermal tissue with results in close agreement with standard off-line analysis and consistent with changes in peripheral blood levels.

SUBMITTER: Nightingale AM 

PROVIDER: S-EPMC6588579 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor.

Nightingale Adrian M AM   Leong Chi Leng CL   Burnish Rachel A RA   Hassan Sammer-Ul SU   Zhang Yu Y   Clough Geraldine F GF   Boutelle Martyn G MG   Voegeli David D   Niu Xize X  

Nature communications 20190621 1


Knowing how biomarker levels vary within biological fluids over time can produce valuable insight into tissue physiology and pathology, and could inform personalised clinical treatment. We describe here a wearable sensor for monitoring biomolecule levels that combines continuous fluid sampling with in situ analysis using wet-chemical assays (with the specific assay interchangeable depending on the target biomolecule). The microfluidic device employs a droplet flow regime to maximise the temporal  ...[more]

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