Ontology highlight
ABSTRACT:
SUBMITTER: Gao S
PROVIDER: S-EPMC6588650 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Gao Shichao S Song Qiao Q Liu Jing J Zhang Xiaomin X Ji Xunming X Wang Peichang P
Cellular and molecular life sciences : CMLS 20190320 14
POLD1, the catalytic subunit of DNA Pol δ, plays an important role in DNA synthesis and DNA damage repair, and POLD1 is downregulated in replicative senescence and mediates cell aging. However, the mechanisms of age-related downregulation of POLD1 expression have not been elucidated. In this study, four potential CpG islands in the POLD1 promoter were found, and the methylation levels of the POLD1 promoter were increased in aging 2BS cells, WI-38 cells and peripheral blood lymphocytes, especiall ...[more]