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Metabolome signature of autism in the human prefrontal cortex.

ABSTRACT: Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with yet incompletely uncovered molecular determinants. Alterations in the abundance of low molecular weight compounds (metabolites) in ASD could add to our understanding of the disease. Indeed, such alterations take place in the urine, plasma and cerebellum of ASD individuals. In this work, we investigated mass-spectrometric signal intensities of 1,366 metabolites in the prefrontal cortex grey matter of 32 ASD and 40 control individuals. 15% of these metabolites showed significantly different intensities in ASD and clustered in 16 metabolic pathways. Of them, ten pathways were altered in urine and blood of ASD individuals (Fisher test, p?

SUBMITTER: Kurochkin I

PROVIDER: S-EPMC6588695 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Metabolome signature of autism in the human prefrontal cortex.

Kurochkin Ilia I Khrameeva Ekaterina E Tkachev Anna A Stepanova Vita V Vanyushkina Anna A Stekolshchikova Elena E Li Qian Q Zubkov Dmitry D Shichkova Polina P Halene Tobias T Willmitzer Lothar L Giavalisco Patrick P Akbarian Schahram S Khaitovich Philipp P

Communications biology 20190621

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with yet incompletely uncovered molecular determinants. Alterations in the abundance of low molecular weight compounds (metabolites) in ASD could add to our understanding of the disease. Indeed, such alterations take place in the urine, plasma and cerebellum of ASD individuals. In this work, we investigated mass-spectrometric signal intensities of 1,366 metabolites in the prefrontal cortex grey matter of 32 ASD and 40 control ...[more]

PMID: 31263778

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