Ontology highlight
ABSTRACT:
SUBMITTER: Blessing WA
PROVIDER: S-EPMC6589647 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Blessing William A WA Okajima Stephen M SM Cubria M Belen MB Villa-Camacho Juan C JC Perez-Viloria Miguel M Williamson Patrick M PM Sabogal Angie N AN Suarez Sebastian S Ang Lay-Hong LH White Suzanne S Flynn Evelyn E Rodriguez Edward K EK Grinstaff Mark W MW Nazarian Ara A
Proceedings of the National Academy of Sciences of the United States of America 20190603 25
Arthrofibrosis is a prevalent condition affecting greater than 5% of the general population and leads to a painful decrease in joint range of motion (ROM) and loss of independence due to pathologic accumulation of periarticular scar tissue. Current treatment options are limited in effectiveness and do not address the underlying cause of the condition: accumulation of fibrotic collagenous tissue. Herein, the naturally occurring peptide hormone relaxin-2 is administered for the treatment of adhesi ...[more]