Ontology highlight
ABSTRACT:
SUBMITTER: Corciulo C
PROVIDER: S-EPMC7418027 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Corciulo Carmen C Castro Cristina M CM Coughlin Thomas T Jacob Samson S Li Zhu Z Fenyö David D Rifkin Daniel B DB Kennedy Oran D OD Cronstein Bruce Neil BN
Scientific reports 20200810 1
Osteoarthritis (OA) affects nearly 10% of the population of the United States and other industrialized countries and, at present, short of surgical joint replacement, there is no therapy available that can reverse the progression of the disease. Adenosine, acting at its A2A receptor (A2AR), is a critical autocrine factor for maintenance of cartilage homeostasis and here we report that injection of liposomal suspensions of either adenosine or a selective A2AR agonist, CGS21680, significantly redu ...[more]