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The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis.

ABSTRACT: Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assurance, a mechanism by which each chromosome receives at least one CO, resulting in all chromosomes exhibiting similar genetic lengths in weak loss-of-function cdka ;1 mutants. Conversely, an increase of CDKA;1 activity resulted in elevated recombination frequencies. Thus, modulation of CDKA;1 kinase activity affects the number and placement of COs along the chromosome axis in a dose-dependent manner.

SUBMITTER: Wijnker E 

PROVIDER: S-EPMC6589648 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in <i>Arabidopsis</i>.

Wijnker Erik E   Harashima Hirofumi H   Müller Katja K   Parra-Nuñez Pablo P   de Snoo C Bastiaan CB   van de Belt Jose J   Dissmeyer Nico N   Bayer Martin M   Pradillo Monica M   Schnittger Arp A  

Proceedings of the National Academy of Sciences of the United States of America 20190604 25

Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in <i>Arabidopsis</i><i>Arabidopsis</i> plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assura  ...[more]

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