Unknown

Dataset Information

0

The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis.

ABSTRACT: Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assurance, a mechanism by which each chromosome receives at least one CO, resulting in all chromosomes exhibiting similar genetic lengths in weak loss-of-function cdka ;1 mutants. Conversely, an increase of CDKA;1 activity resulted in elevated recombination frequencies. Thus, modulation of CDKA;1 kinase activity affects the number and placement of COs along the chromosome axis in a dose-dependent manner.

SUBMITTER: Wijnker E 

PROVIDER: S-EPMC6589648 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in <i>Arabidopsis</i>.

Wijnker Erik E   Harashima Hirofumi H   Müller Katja K   Parra-Nuñez Pablo P   de Snoo C Bastiaan CB   van de Belt Jose J   Dissmeyer Nico N   Bayer Martin M   Pradillo Monica M   Schnittger Arp A  

Proceedings of the National Academy of Sciences of the United States of America 20190604 25

Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in <i>Arabidopsis</i><i>Arabidopsis</i> plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assura  ...[more]

Similar Datasets

Unknown The Arabidopsis Cdk1/Cdk2 homolog CDKA;1 controls chromosome axis assembly during plant meiosis.
| S-EPMC6996576 | biostudies-literature
Unknown The Arabidopsis Cdk1/Cdk2 homolog CDKA;1 controls chromosome axis assembly during plant meiosis
| S-SCDT-EMBOJ-2019-101625 | biostudies-other
Unknown Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
| S-EPMC6344228 | biostudies-literature
Unknown The recombination landscape in Arabidopsis thaliana F2 populations.
| S-EPMC3313057 | biostudies-literature
Unknown The Arabidopsis MutS homolog AtMSH4 functions at an early step in recombination: evidence for two classes of recombination in Arabidopsis.
| S-EPMC529542 | biostudies-literature
Genomics Cdk1 controls global epigenetic landscape in embryonic stem cells
2020-04-04 | GSE134645 | GEO
Unknown Loss of DNA methylation affects the recombination landscape in Arabidopsis.
| S-EPMC3326504 | biostudies-literature
Unknown Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2.
| S-EPMC2668819 | biostudies-literature
Proteomics,Multiomics Cdk1 controls global epigenetic landscape in embryonic stem cells
2020-10-05 | PXD015173 | Pride
Unknown CDK1 and CDK2 regulate NICD1 turnover and the periodicity of the segmentation clock.
| S-EPMC6607002 | biostudies-literature