Ontology highlight
ABSTRACT:
SUBMITTER: Kaneko T
PROVIDER: S-EPMC6590088 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Kaneko Tomonori T Huang Haiming H Zhao Bing B Li Lei L Liu Huadong H Voss Courtney K CK Wu Chenggang C Schiller Martin R MR Li Shawn Shun-Cheng SS
Science signaling 20100504 120
Cellular functions require specific protein-protein interactions that are often mediated by modular domains that use binding pockets to engage particular sequence motifs in their partners. Yet, how different members of a domain family select for distinct sequence motifs is not fully understood. The human genome encodes 120 Src homology 2 (SH2) domains (in 110 proteins), which mediate protein-protein interactions by binding to proteins with diverse phosphotyrosine (pTyr)-containing sequences. The ...[more]